"Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE"

Christina Humer; Christoph Romanin

doi:10.1016/j.ceca.2022.102574

"Functional communication between IP₃R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE"

Cell Calcium. 2022 Jun:104:102574. doi: 10.1016/j.ceca.2022.102574. Epub 2022 Mar 29.

Authors

Christina Humer¹, Christoph Romanin²

Affiliations

¹ Institute of Biophysics, Johannes Kepler University Linz, Gruberstraße, Linz, 404020 Austria.
² Institute of Biophysics, Johannes Kepler University Linz, Gruberstraße, Linz, 404020 Austria. Electronic address: christoph.romanin@jku.at.

PMID: 35395520
DOI: 10.1016/j.ceca.2022.102574

Abstract

The family of stromal interaction molecules (STIMs), comprising the homologs STIM1 and STIM2 with their different isoforms, has an intricate role in cellular calcium (Ca²⁺) homeostasis and signal transduction. While this is predominantly accomplished in concert with plasma membrane Orai proteins, STIM1 and STIM2 show essential functional differences, as was recently further elucidated by Ahmad et al. [1].

Keywords: Calcium signaling; STIM2, STIM1, IP3 receptor, Orai1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calcium Signaling*
Calcium* / metabolism
Cell Communication
Membrane Proteins / metabolism
ORAI1 Protein / metabolism
Stromal Interaction Molecule 1 / metabolism
Stromal Interaction Molecule 2 / metabolism

Substances

Membrane Proteins
ORAI1 Protein
Stromal Interaction Molecule 1
Stromal Interaction Molecule 2
Calcium