Oncogene Convergence in Extrachromosomal DNA Hubs

Cancer Discov. 2022 May 2;12(5):1195-1198. doi: 10.1158/2159-8290.CD-22-0076.


Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification. Several recent discoveries of ecDNA hubs-local congregations of ecDNAs in the nucleus-highlight unique features of ecDNA biology that may contribute to higher oncogene expression and rapid tumor evolution.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cell Nucleus
  • DNA / genetics
  • Gene Amplification
  • Humans
  • Neoplasms* / genetics
  • Neoplasms* / pathology
  • Oncogenes*


  • DNA