Interplay Between Non-Coding RNAs and Programmed Cell Death Proteins

Soudeh Ghafouri-Fard; Bashdar Mahmud Hussen; Mahdi Mohaqiq; Hamed Shoorei; Aria Baniahmad; Mohammad Taheri; Elena Jamali

doi:10.3389/fonc.2022.808475

Interplay Between Non-Coding RNAs and Programmed Cell Death Proteins

Front Oncol. 2022 Mar 23:12:808475. doi: 10.3389/fonc.2022.808475. eCollection 2022.

Authors

Soudeh Ghafouri-Fard¹, Bashdar Mahmud Hussen², Mahdi Mohaqiq^{3

4}, Hamed Shoorei⁵, Aria Baniahmad⁶, Mohammad Taheri^{6

7}, Elena Jamali⁸

Affiliations

¹ Department of Medical Genetics, School of Medicine, Shahid Beheshti Universality of Medical Sciences, Tehran, Iran.
² Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
³ School of Advancement, Centennial College, Toronto, ON, Canada.
⁴ The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
⁵ Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
⁶ Institute of Human Genetics, Jena University Hospital, Jena, Germany.
⁷ Urology and Nephrology Research Center, Shahid Beheshti Universality of Medical Sciences, Tehran, Iran.
⁸ Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti Universality of Medical Sciences, Tehran, Iran.

Abstract

Programmed cell death (PDCD) family of proteins includes at least 12 members, function of seven of them being more investigated. These members are PDCD1, PDCD2, PDCD4, PDCD5, PDCD6, PDCD7 and PDCD10. Consistent with the important roles of these proteins in the regulation of apoptosis, dysregulation of PDCDs is associated with diverse disorders ranging from intervertebral disc degeneration, amyotrophic lateral sclerosis, immune thrombocytopenia, type 1 diabetes, congenital hypothyroidism, Alzheimer's disease to different types of cancers. More recently, the interaction between non-coding RNAs and different members of PDCD family is being discovered. In the current study, we described the functional interactions between PDCDs and two classes of non-coding RNAs, namely microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). miR-21 and miR-183 are two miRNAs whose interactions with PDCDs have been assessed in different contexts. The lncRNAs interaction with PDCDs is mainly assessed in the context of neoplasia indicating the role of MALAT1, MEG3, SNHG14 and LINC00473 in this process.

Keywords: biomarker; expression; lncRNA; miRNA; programmed cell death protein.

Publication types

Review