The Role of Interleukin-6 Family Members in Cardiovascular Diseases

Yongqi Feng; Di Ye; Zhen Wang; Heng Pan; Xiyi Lu; Menglong Wang; Yao Xu; Junping Yu; Jishou Zhang; Mengmeng Zhao; Shuwan Xu; Wei Pan; Zheng Yin; Jing Ye; Jun Wan

doi:10.3389/fcvm.2022.818890

The Role of Interleukin-6 Family Members in Cardiovascular Diseases

Front Cardiovasc Med. 2022 Mar 23:9:818890. doi: 10.3389/fcvm.2022.818890. eCollection 2022.

Authors

Yongqi Feng^{1

2

3}, Di Ye^{1

2

3}, Zhen Wang^{1

2

3}, Heng Pan^{1

2

3}, Xiyi Lu^{1

2

3}, Menglong Wang^{1

2

3}, Yao Xu^{1

2

3}, Junping Yu^{1

2

3}, Jishou Zhang^{1

2

3}, Mengmeng Zhao^{1

2

3}, Shuwan Xu^{1

2

3}, Wei Pan^{1

2

3}, Zheng Yin^{1

2

3}, Jing Ye^{1

2

3}, Jun Wan^{1

2

3}

Affiliations

¹ Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
² Cardiovascular Research Institute, Wuhan University, Wuhan, China.
³ Hubei Key Laboratory of Cardiology, Wuhan, China.

Abstract

Cardiovascular disease is one of the main causes of human mortality. Cytokines play crucial roles in the development of cardiovascular disease. Interleukin (IL)-6 family members are a series of cytokines, including IL-6, IL-11, IL-30, IL-31, OSM, LIF, CNTF, CT-1, CT-2, and CLC, that regulate multiple biological effects. Experimental and clinical evidence shows that IL-6 family members are closely related to cardiovascular diseases such as atherosclerosis, hypertension, aortic dissection, cardiac fibrosis, and cardiomyopathy. This review mainly discusses the role of IL-6 family members in cardiovascular disease for the sake of identifying possible intervention targets for cardiovascular disease prevention and treatment.

Keywords: IL-6 family cytokines; atherosclerosis; cardiac remodeling; cardiovascular diseases; coronary artery disease.

Publication types

Review