Tricyclic antidepressant overdose. A review

JAMA. 1987 Jan 23-30;257(4):521-6.


Significant advances in diagnosis and management of tricyclic antidepressant overdose have occurred in recent years. This article reviews epidemiologic, pharmacologic, and therapeutic information to provide a systematic approach to these potentially life-threatening overdoses. The tricyclics are discussed as a group, with individual drugs specified when established differences exist.

Publication types

  • Review

MeSH terms

  • Antidepressive Agents, Tricyclic / metabolism
  • Antidepressive Agents, Tricyclic / poisoning*
  • Cardiovascular Diseases / chemically induced
  • Cardiovascular Diseases / therapy
  • Central Nervous System Diseases / chemically induced
  • Central Nervous System Diseases / therapy
  • Emergencies
  • Humans


  • Antidepressive Agents, Tricyclic