Effects of specific collagen peptide supplementation combined with resistance training on Achilles tendon properties

Scand J Med Sci Sports. 2022 Jul;32(7):1131-1141. doi: 10.1111/sms.14164. Epub 2022 Apr 20.


The purpose of this study was to investigate the effect of specific collagen peptides (SCP) combined with resistance training (RT) on changes in tendinous and muscular properties. In a randomized, placebo-controlled study, 40 healthy male volunteers (age: 26.3 ± 4.0 years) completed a 14 weeks high-load resistance training program. One group received a daily dosage of 5g SCP while the other group received 5g of a placebo (PLA) supplement. Changes in Achilles tendon cross-sectional area (CSA), tendon stiffness, muscular strength, and thickness of the plantar flexors were measured. The SCP supplementation led to a significantly (p = 0.002) greater increase in tendon CSA (+11.0%) compared with the PLA group (+4.7%). Moreover, the statistical analysis revealed a significantly (p = 0.014) greater increase in muscle thickness in the SCP group (+7.3%) compared with the PLA group (+2.7%). Finally, tendon stiffness and muscle strength increased in both groups, with no statistical difference between the groups. In conclusion, the current study shows that the supplementation of specific collagen peptides combined with RT is associated with a greater hypertrophy in tendinous and muscular structures than RT alone in young physically active men. These effects might play a role in reducing tendon stress (i.e., deposition of collagen in load-bearing structures) during daily activities.

Keywords: cross-sectional area; protein supplementation; stiffness; tendon.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Achilles Tendon* / physiology
  • Adult
  • Collagen
  • Dietary Supplements
  • Humans
  • Male
  • Muscle Strength / physiology
  • Muscle, Skeletal / physiology
  • Peptides
  • Polyesters / pharmacology
  • Resistance Training*
  • Young Adult


  • Peptides
  • Polyesters
  • Collagen