Linking circadian rhythms to microbiome-gut-brain axis in aging-associated neurodegenerative diseases

Ageing Res Rev. 2022 Jun;78:101620. doi: 10.1016/j.arr.2022.101620. Epub 2022 Apr 8.


Emerging evidence suggests that both disruption of circadian rhythms and gut dysbiosis are closely related to aging-associated neurodegenerative diseases. Over the last decade, the microbiota-gut-brain axis has been an emerging field and revolutionized studies in pathology, diagnosis, and treatment of neurological disorders. Crosstalk between the brain and gut microbiota can be accomplished via the endocrine, immune, and nervous system. Recent studies have shown that the composition and diurnal oscillation of gut microbiota are influenced by host circadian rhythms. This provides a new perspective for investigating the microbiome-gut-brain axis. We aim to review current understanding and research on the dynamic interaction between circadian rhythms and the microbiome-gut-brain axis. Furthermore, we will address the possible neurodegenerative disease contribution through circadian rhythms and microbiome-gut-brain axis crosstalk.

Keywords: Alzheimer’s disease; Central nervous system; Circadian disruption; Gut dysbiosis; Gut-brain axis; Parkinson’s disease.

Publication types

  • Review

MeSH terms

  • Aging
  • Brain / physiology
  • Brain-Gut Axis
  • Circadian Rhythm
  • Gastrointestinal Microbiome* / physiology
  • Humans
  • Neurodegenerative Diseases*