Recent Advances in the Synthesis of Isoquinoline-Fused Benzimidazoles

Dylan J Twardy; Kraig A Wheeler; Béla Török; Roman Dembinski

doi:10.3390/molecules27072062

Recent Advances in the Synthesis of Isoquinoline-Fused Benzimidazoles

Molecules. 2022 Mar 23;27(7):2062. doi: 10.3390/molecules27072062.

Authors

Dylan J Twardy¹, Kraig A Wheeler², Béla Török³, Roman Dembinski^{1

4}

Affiliations

¹ Department of Chemistry, Oakland University, 146 Library Dr., Rochester, MI 48309, USA.
² Department of Chemistry, Whitworth University, 300 W. Hawthorne Rd., Spokane, WA 99251, USA.
³ Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd., Boston, MA 02125, USA.
⁴ Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Łódź, Poland.

Abstract

This review includes recent developments in the synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines with particular attention given to categorizing protocols based on the structural features of the ring architecture and crystallographically characterized reaction products.

Keywords: benzimidazo[2,1-a]isoquinoline; benzimidazole; benzo[4,5]imidazo[2,1-a]isoquinoline; isoquinoline; nitrogen heterocycles.

Publication types

Review

MeSH terms

Benzimidazoles* / chemistry
Cyclization
Isoquinolines* / chemistry

Substances

Benzimidazoles
Isoquinolines

Abstract

Publication types

MeSH terms

Substances

Grants and funding