The molecular genetics of cancer

Science. 1987 Jan 16;235(4786):305-11. doi: 10.1126/science.3541204.


The search for genetic damage in neoplastic cells now occupies a central place in cancer research. Diverse examples of such damage are in hand, and they in turn hint at biochemical explanations for neoplastic growth. The way may be open to solve the riddles of how normal cells govern their replication and why cancer cells do not.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Chromosome Deletion
  • DNA Damage
  • DNA, Neoplasm / genetics
  • Gene Amplification
  • Humans
  • Mutation
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Oncogenes*
  • Proto-Oncogenes*
  • Retroviridae / genetics
  • Translocation, Genetic


  • DNA, Neoplasm