The metabolism of aromatic amines

Xenobiotica. Oct-Nov 1986;16(10-11):933-55. doi: 10.3109/00498258609038975.

Abstract

Aromatic amines are of general interest in drug metabolism and some are a health hazard, particularly as bladder carcinogens. Conditions for the biological ring- and N-oxidation of aniline and its derivatives are reviewed. The metabolism of 2-naphthylamine and aminobiphenyls and the involvement of metabolites of aromatic amines in bladder cancer is discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Biotransformation
  • Carcinogens / metabolism*
  • Humans
  • Polycyclic Compounds / metabolism*
  • Urinary Bladder Neoplasms / chemically induced*

Substances

  • Carcinogens
  • Polycyclic Compounds