REIA: A database for cancer A-to-I RNA editing with interactive analysis

Int J Biol Sci. 2022 Mar 14;18(6):2472-2483. doi: 10.7150/ijbs.69458. eCollection 2022.


Epitranscriptomic changes caused by adenosine-to-inosine (A-to-I) RNA editing contribute to the pathogenesis of human cancers; however, only a small fraction of the millions editing sites detected so far has clear functionality. To facilitate more in-depth studies on the editing, this paper offers REIA (, an interactive web server that analyses and visualizes the association between human cancers and A-to-I RNA editing sites (RESs). As a comprehensive database, REIA curates not only 8,447,588 RESs from 9,895 patients across 34 cancers, where 33 are from TCGA and 1 from GEO, but also 13 different types of multi-omic data for the cancers. As an interactive server, REIA provides various options for the user to specify the interested sites, to browse their annotation/editing level/profile in cancer, and to compare the difference in multi-omic features between editing and non-editing groups. From the editing profiles, REIA further detects 658 peptides that are supported by mass spectrum data but not yet covered in any prior works.

Keywords: A-to-I RNA editing; Cancer; Database; Interactive analysis; Multi-omics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / genetics
  • Adenosine / metabolism
  • Humans
  • Inosine / genetics
  • Inosine / metabolism
  • Neoplasms* / genetics
  • RNA
  • RNA Editing* / genetics


  • Inosine
  • RNA
  • Adenosine