A case of bone lesion in a patient with relapsed chronic lymphocytic leukemia and review of the literature

Francesca Bacchiarri; Alessandro Gozzetti; Nicola Mondanelli; Stefano Lazzi; Monica Bocchia

doi:10.1002/ccr3.5379

A case of bone lesion in a patient with relapsed chronic lymphocytic leukemia and review of the literature

Clin Case Rep. 2022 Apr 4;10(4):e05379. doi: 10.1002/ccr3.5379. eCollection 2022 Apr.

Authors

Francesca Bacchiarri¹, Alessandro Gozzetti¹, Nicola Mondanelli², Stefano Lazzi³, Monica Bocchia¹

Affiliations

¹ Department of Hematology University of Siena Siena Italy.
² Department of Orthopedic Surgery University of Siena Siena Italy.
³ Anatomic Pathology Department University of Siena Siena Italy.

Abstract

Skeletal involvement in CLL is very rare. We present a case of ileum bone lesion during in a patient receiving 5th line of therapy. Despite radiotherapy and salvage therapies, subsequent bone lesions led to a fatal outcome. Further studies on the mechanism by which bone disease develops are currently needed.

Keywords: chronic lymphocytic leukemia; hypercalcemia; osteolysis.

Publication types

Case Reports