An optimized platform for efficient siRNA delivery into human NK cells

Eur J Immunol. 2022 Jul;52(7):1190-1193. doi: 10.1002/eji.202149710. Epub 2022 Apr 22.


The molecular networks that regulate natural killer (NK) cell functions are not completely understood. Here, we present a workflow for efficient delivery of siRNA into human NK cells without compromising viability. This methodology represents a promising approach for rapidly interrogating gene functions in primary human NK cells.

Keywords: Gene regulation; Molecular biology; NK cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Killer Cells, Natural*
  • RNA, Small Interfering / genetics


  • RNA, Small Interfering