Fungus packs a punch in the gut

Daniel H Cho; Gloria B Choi

doi:10.1016/j.immuni.2022.03.012

Fungus packs a punch in the gut

Immunity. 2022 Apr 12;55(4):586-588. doi: 10.1016/j.immuni.2022.03.012.

Authors

Daniel H Cho¹, Gloria B Choi²

Affiliations

¹ Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
² Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: gbchoi@mit.edu.

PMID: 35417672
DOI: 10.1016/j.immuni.2022.03.012

Abstract

The impact of intestinal fungi on host physiology and their mechanisms of interaction are incompletely understood. In a recent issue of Cell, Leonardi et al. (2022) showed that mucosal fungi induce intestinal Th17 cells to produce IL-22 and IL-17A. IL-22 acts on the gut epithelium to protect barrier integrity, whereas IL-17 acts on IL-17RA⁺ neurons to enhance sociability.

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MeSH terms

Fungi
Receptors, Interleukin-17*
Th17 Cells*

Substances

Receptors, Interleukin-17