Efficacy of Azithromycin plus Glucocorticoid Adjuvant Therapy on Serum Inflammatory Factor Levels and Incidence of Adverse Reactions in Children with Mycoplasma Pneumonia

Yingdong Cao; Binbin Dong; Xuecheng Wang; Chunrong Wang

doi:10.1155/2022/1207512

Efficacy of Azithromycin plus Glucocorticoid Adjuvant Therapy on Serum Inflammatory Factor Levels and Incidence of Adverse Reactions in Children with Mycoplasma Pneumonia

Evid Based Complement Alternat Med. 2022 Apr 4:2022:1207512. doi: 10.1155/2022/1207512. eCollection 2022.

Authors

Yingdong Cao¹, Binbin Dong², Xuecheng Wang³, Chunrong Wang⁴

Affiliations

¹ Department of Pharmacy, Hainan Women and Children's Medical Center, Haikou, Hainan 570100, China.
² Department of Pediatrics, Huashan Hospital, Fudan University, Shanghai 200040, China.
³ Department of Pediatrics, Dongyang Hospital Affiliated to Wenzhou Medical University, Dongyang 322100, China.
⁴ Department of Pediatrics, Shanghai Jiading Hospital of Traditional Chinese Medicine, Shanghai 201899, China.

Abstract

Objective: This study was designed to explore the efficacy of azithromycin plus glucocorticoid adjuvant therapy on the levels of serum inflammatory factors and the incidence of adverse reactions in children with mycoplasma pneumonia.

Method: A total of 90 eligible children with mycoplasma pneumonia in our hospital from January 2019 to January 2020 were recruited. They were assigned to receive either azithromycin (control group) or azithromycin plus glucocorticoid (experimental group) according to the order of admission. Outcome measures included clinical efficacy, serum inflammatory factor indicators, lung function, clinical symptom mitigation, length of hospital stay, immune function, incidence of adverse reactions, and psychological status of the eligible children.

Results: Azithromycin plus glucocorticoid was associated with a significantly higher total clinical efficacy compared with azithromycin (P < 0.05). No significant differences were found in the serum inflammatory factor indices between the two groups (P > 0.05). The children given azithromycin plus glucocorticoid showed lower levels of serum inflammatory factors versus those given azithromycin alone (P < 0.001). Azithromycin plus glucocorticoid outperformed the monotherapy of azithromycin in terms of lung function (P < 0.001). Children after azithromycin plus glucocorticoid therapy had a faster clinical symptom disappearance and shorter length of hospital stay compared with after azithromycin alone (P < 0.001). Azithromycin plus glucocorticoid resulted in higher levels of immune function indices compared with azithromycin alone (P < 0.001). Azithromycin plus glucocorticoid was associated with a lower incidence of adverse reactions compared with azithromycin (P < 0.05). Lower Children's Depression Inventory (CDI) scores were witnessed in children given azithromycin plus glucocorticoid compared with monotherapy of azithromycin (P < 0.001).

Conclusion: Azithromycin plus glucocorticoid in children with mycoplasma pneumonia can effectively improve the clinical indicators of the children with promising efficacy and high safety, which is worthy of promotion and application.

Publication types

Retracted Publication