Correlation between human papillomavirus infection and reproduction

Ginekol Pol. 2022;93(4):329-333. doi: 10.5603/GP.a2021.0175. Epub 2022 Apr 14.


Human papillomavirus (HPV) is one of the most common sexually transmitted infectious viruses among men and women of reproductive age throughout the world. Pregnant women are susceptible during pregnancy and most infections of them are self-limiting infections, which can be removed by their autoimmunity, while the persistent infections are associated with precancerous lesions and cancer of the anogenital mucosa in women and men. In addition, HPV infection may also affect reproductive health and fertility. The effect of HPV on female fertility requires further study, but HPV influences sperm parameters. Furthermore, whether HPV infection alters the effect of assisted reproductive technology and whether there is an association between it and assisted reproductive technology (ART) outcomes is unknown. It is considered that the relationship between HPV infection and spontaneous abortion (SA), assisted reproductive technology (ART) outcomes and spontaneous preterm birth (sPTB) has profound implications for the medical care of pregnant and infertile women. This paper reviews the relationship between human papillomavirus infection during pregnancy and SA, sPTB and ART in reproduction, and reviews the relationship between human papillomavirus and human fertility by summarizing the recent domestic and foreign literature.

Keywords: assisted reproductive technology; human papillomavirus infection; reproduction; spontaneous abortion; spontaneous preterm birth.

Publication types

  • Review

MeSH terms

  • Abortion, Spontaneous*
  • Female
  • Human Papillomavirus Viruses
  • Humans
  • Infant, Newborn
  • Infertility, Female*
  • Male
  • Papillomavirus Infections* / complications
  • Pregnancy
  • Premature Birth*
  • Semen