HIV: the changing paradigm

Sian Raubinger; Frederick J Lee; Angie N Pinto

doi:10.1111/imj.15739

HIV: the changing paradigm

Intern Med J. 2022 Apr;52(4):542-549. doi: 10.1111/imj.15739.

Authors

Sian Raubinger¹, Frederick J Lee^{1

2}, Angie N Pinto^{1

3}

Affiliations

¹ Department of Infectious Diseases and Microbiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
² University of Sydney, Sydney, New South Wales, Australia.
³ The Kirby Institute, UNSW Australia, Sydney, New South Wales, Australia.

PMID: 35419962
DOI: 10.1111/imj.15739

Abstract

The past four decades have seen enormous progress in the diagnosis and management of human immunodeficiency virus (HIV) infection. There have been significant advances spanning the approval of the first antiretroviral agents, the advent of combination antiretroviral therapy to single tablet regimens with minimal toxicity. Although these remarkable developments have on the surface led to the 'end of AIDS', there are still key populations being left behind. This clinical update will describe the diagnosis and management of HIV, and the changing paradigms that have seen HIV transform from a life-limiting condition to a manageable chronic disease over a few decades.

Keywords: AIDS; HIV; antiretrovirals.

MeSH terms

Anti-HIV Agents* / therapeutic use
Anti-Retroviral Agents / therapeutic use
Chronic Disease
HIV Infections* / diagnosis
HIV Infections* / drug therapy
HIV Infections* / epidemiology
Humans

Substances

Anti-HIV Agents
Anti-Retroviral Agents