An intrinsic membrane glycoprotein of the lens

Curr Eye Res. 1986 Dec;5(12):949-58. doi: 10.3109/02713688608995176.


A major glycoprotein of relative molecular weight of 130,000 daltons of chick lens cell membranes was identified by Concanavalin-A staining and enriched for by Con A-Sepharose chromatography. Using both Con A binding and immunological analyses with a specific polyclonal antibody, the glycoprotein was detected in chick lens epithelium, annular pad, cortex and nucleus. Localization to the plasma membranes of lens cells was demonstrated by immunofluorescence. A similar protein, which cross-reacts with the antibody to the chick protein and also binds Con A was demonstrated in human and bovine lenses.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cattle
  • Chickens
  • Concanavalin A
  • Crystallins / metabolism*
  • Electrophoresis, Polyacrylamide Gel
  • Glycoproteins / metabolism*
  • Humans
  • Immunologic Techniques
  • Infant, Newborn
  • Lens, Crystalline / metabolism*
  • Lens, Crystalline / ultrastructure
  • Membrane Proteins / metabolism*


  • Crystallins
  • Glycoproteins
  • Membrane Proteins
  • Concanavalin A