Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut

FEBS Lett. 1987 Jan 26;211(2):169-74. doi: 10.1016/0014-5793(87)81430-8.


By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.

MeSH terms

  • Animals
  • Glucagon / metabolism*
  • Glucagon / physiology
  • Ileum / metabolism*
  • Insulin / metabolism*
  • Intestinal Mucosa / metabolism*
  • Peptides / metabolism*
  • Peptides / physiology
  • Swine


  • Insulin
  • Peptides
  • Glucagon