Therapeutic activity of lactate 12% lotion in the treatment of ichthyosis. Active versus vehicle and active versus a petrolatum cream

J Am Acad Dermatol. 1986 Dec;15(6):1253-8. doi: 10.1016/s0190-9622(86)70299-5.


Lactate 12% lotion was significantly more effective than both its vehicle and a petrolatum-based cream in the treatment of ichthyosis. The treatment regimen was twice-daily application for 4 weeks with evaluations weekly during the treatment period and for 2 weeks after treatment was stopped. Vulgaris, lamellar, sex-linked, Netherton's, and epidermolytic hyperkeratotic forms of ichthyosis were significantly improved by treatment with lactate 12% lotion. This new therapeutic modality expands the scope and extent of ichthyotic conditions that may now be successfully treated.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Humans
  • Ichthyosis / drug therapy*
  • Ichthyosis / genetics
  • Lactates / therapeutic use*
  • Lactic Acid
  • Middle Aged
  • Petrolatum / therapeutic use*
  • Pharmaceutical Vehicles


  • Lactates
  • Pharmaceutical Vehicles
  • Lactic Acid
  • Petrolatum