ENO1 and Cancer
- PMID: 35434271
- PMCID: PMC8987341
- DOI: 10.1016/j.omto.2021.12.026
ENO1 and Cancer
Abstract
α-Enolase (ENO1), also known as 2-phospho-D-glycerate hydrolase, is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglyceric acid to phosphoenolpyruvic acid during glycolysis. It is a multifunctional oncoprotein that is present both in cell surface and cytoplasm, contributing to hit seven out of ten "hallmarks of cancer." ENO1's glycolytic function deregulates cellular energetic, sustains tumor proliferation, and inhibits cancer cell apoptosis. Moreover, ENO1 evades growth suppressors and helps tumors to avoid immune destruction. Besides, ENO1 "moonlights" on the cell surface and acts as a plasminogen receptor, promoting cancer invasion and metastasis by inducing angiogenesis. Overexpression of ENO1 on a myriad of cancer types together with its localization on the tumor surface makes it a great prognostic and diagnostic cancer biomarker as well as an accessible oncotherapeutic target. This review summarizes the up-to-date knowledge about the relationship between ENO1 and cancer, examines ENO1's potential as a cancer biomarker, and discusses ENO1's role in novel onco-immunotherapeutic strategies.
Keywords: ENO1; cancer biomarker; glycolysis; hallmarks of cancer; oncotherapy; tumorigenesis.
© 2022 The Authors.
Conflict of interest statement
The authors declare no competing interests.
Figures
Similar articles
-
Alpha-Enolase: Emerging Tumor-Associated Antigen, Cancer Biomarker, and Oncotherapeutic Target.Front Genet. 2021 Jan 28;11:614726. doi: 10.3389/fgene.2020.614726. eCollection 2020. Front Genet. 2021. PMID: 33584813 Free PMC article. Review.
-
Progress in the biological function of alpha-enolase.Anim Nutr. 2016 Mar;2(1):12-17. doi: 10.1016/j.aninu.2016.02.005. Epub 2016 Mar 2. Anim Nutr. 2016. PMID: 29767008 Free PMC article. Review.
-
Role of ENO1 and its targeted therapy in tumors.J Transl Med. 2024 Nov 14;22(1):1025. doi: 10.1186/s12967-024-05847-8. J Transl Med. 2024. PMID: 39543641 Free PMC article. Review.
-
ENO1 monoclonal antibody inhibits invasion, proliferation and clone formation of cervical cancer cells.Am J Cancer Res. 2021 May 15;11(5):1946-1961. eCollection 2021. Am J Cancer Res. 2021. PMID: 34094663 Free PMC article.
-
Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation.Mol Cell. 2022 Jul 21;82(14):2666-2680.e11. doi: 10.1016/j.molcel.2022.05.019. Epub 2022 Jun 15. Mol Cell. 2022. PMID: 35709751
Cited by
-
ALDH1A3 is the switch that determines the balance of ALDH+ and CD24-CD44+ cancer stem cells, EMT-MET, and glucose metabolism in breast cancer.Oncogene. 2024 Oct;43(43):3151-3169. doi: 10.1038/s41388-024-03156-4. Epub 2024 Sep 9. Oncogene. 2024. PMID: 39251846 Free PMC article.
-
New Pathophysiological Insights from Serum Proteome Profiling in Equine Atypical Myopathy.ACS Omega. 2024 Jan 29;9(6):6505-6526. doi: 10.1021/acsomega.3c06647. eCollection 2024 Feb 13. ACS Omega. 2024. PMID: 38371826 Free PMC article.
-
Long non-coding RNA NMRAL2P promotes glycolysis and reduces ROS in head and neck tumors by interacting with the ENO1 protein and promoting GPX2 transcription.PeerJ. 2023 Oct 2;11:e16140. doi: 10.7717/peerj.16140. eCollection 2023. PeerJ. 2023. PMID: 37810778 Free PMC article.
-
Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression.Cell Biosci. 2024 Jun 7;14(1):74. doi: 10.1186/s13578-024-01249-x. Cell Biosci. 2024. PMID: 38849850 Free PMC article.
-
Potential Role of Seven Proteomics Tissue Biomarkers for Diagnosis and Prognosis of Prostate Cancer in Urine.Diagnostics (Basel). 2022 Dec 16;12(12):3184. doi: 10.3390/diagnostics12123184. Diagnostics (Basel). 2022. PMID: 36553191 Free PMC article.
References
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
