Synchronous uterine serous carcinoma and ovarian sex cord stromal tumor (thecoma)-A rare first case report

Indian J Pathol Microbiol. 2022 Apr-Jun;65(2):437-439. doi: 10.4103/IJPM.IJPM_1424_20.


Synchronous endometrial and ovarian carcinoma is a rare instance and it accounts for 50 to 70% of all synchronous female genital tract tumors. However, it is very rare to find synchronous endometrial carcinoma and ovarian sex cord-stromal tumor (thecoma). The present case is a 75-year-old woman with a complaint of post-menopausal vaginal bleeding. Radiologically, the magnetic resonance imaging (MRI) pelvis revealed altered signal intensity mass in the uterus. Frozen section and routine histopathological examination were done on radical hysterectomy. Microscopically, serous carcinoma involving uterine corpus and left Fallopian tube was identified along with the unusual finding of contralateral ovarian sex cord-stromal tumor (thecoma), which was confirmed on immunohistochemical examination. It is a very rare association and is first reported in the present study after a thorough search of the published literature. Their relationship based on a high level of estrogen produced by the hyperactive ovary is controversial as serous carcinomas are less hormone-dependent.

Keywords: Serous carcinoma; sex cord–stromal tumor; synchronous tumors; thecoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carcinoma* / pathology
  • Cystadenocarcinoma, Serous* / diagnostic imaging
  • Cystadenocarcinoma, Serous* / surgery
  • Female
  • Humans
  • Ovarian Neoplasms* / diagnostic imaging
  • Ovarian Neoplasms* / surgery
  • Sex Cord-Gonadal Stromal Tumors* / diagnosis
  • Sex Cord-Gonadal Stromal Tumors* / pathology
  • Thecoma* / diagnostic imaging
  • Thecoma* / surgery
  • Uterine Hemorrhage
  • Uterine Neoplasms* / diagnosis
  • Uterine Neoplasms* / pathology