Primary pulmonary diffuse large B-cell lymphoma is a rare type of extranodal lymphoma with PET/CT manifestations of consolidations, ground-glass opacities, and high 18F-FDG uptake. Because of its rarity and the lack of typical imaging features, it can hardly be diagnosed through PET/CT. The central cavitation was occasionally seen in pulmonary diffuse large B-cell lymphoma and may be a key imaging feature in differential diagnoses. In this report, we describe an 80-year-old man diagnosed as having pulmonary diffuse large B-cell lymphoma, which demonstrated the central cavitation detected by 18F-FDG PET/CT.
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