PEGR: a flexible management platform for reproducible epigenomic and genomic research

Genome Biol. 2022 Apr 19;23(1):99. doi: 10.1186/s13059-022-02671-5.


Reproducibility is a significant challenge in (epi)genomic research due to the complexity of experiments composed of traditional biochemistry and informatics. Recent advances have exacerbated this as high-throughput sequencing data is generated at an unprecedented pace. Here, we report the development of a Platform for Epi-Genomic Research (PEGR), a web-based project management platform that tracks and quality controls experiments from conception to publication-ready figures, compatible with multiple assays and bioinformatic pipelines. It supports rigor and reproducibility for biochemists working at the bench, while fully supporting reproducibility and reliability for bioinformaticians through integration with the Galaxy platform.

Keywords: Data management system; Galaxy; Genomics; High-throughput sequencing; Reproducibility; Science gateway.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computational Biology
  • Epigenomics*
  • Genome
  • Genomics*
  • Reproducibility of Results
  • Software