Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis

Cheng Wen; Bowei Li; Lei Nie; Ling Mao; Yuanpeng Xia

doi:10.3389/fcell.2022.804247

Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis

Front Cell Dev Biol. 2022 Apr 4:10:804247. doi: 10.3389/fcell.2022.804247. eCollection 2022.

Authors

Cheng Wen¹, Bowei Li¹, Lei Nie¹, Ling Mao¹, Yuanpeng Xia¹

Affiliation

¹ Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Abstract

Atherosclerosis (AS) is universally defined as chronic vascular inflammation induced by dyslipidaemia, obesity, hypertension, diabetes and other risk factors. Extracellular vesicles as information transmitters regulate intracellular interactions and their important cargo circular RNAs are involved in the pathological process of AS. In this review, we summarize the current data to elucidate the emerging roles of extracellular vesicle-derived circular RNAs (EV-circRNAs) in AS and the mechanism by which EV-circRNAs affect the development of AS. Additionally, we discuss their vital role in the progression from risk factors to AS and highlight their great potential for use as diagnostic biomarkers of and novel therapeutic strategies for AS.

Keywords: Biomarker (BM); atherosclerosis; circular RNA (circRNA); extracellular vesicle; therapy.

Publication types

Review