Hippocampal place codes are gated by behavioral engagement

Nat Neurosci. 2022 May;25(5):561-566. doi: 10.1038/s41593-022-01050-4. Epub 2022 Apr 21.


As animals explore an environment, the hippocampus is thought to automatically form and maintain a place code by combining sensory and self-motion signals. Instead, we observed an extensive degradation of the place code when mice voluntarily disengaged from a virtual navigation task, remarkably even as they continued to traverse the identical environment. Internal states, therefore, can strongly gate spatial maps and reorganize hippocampal activity even without sensory and self-motion changes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Hippocampus
  • Mice
  • Space Perception
  • Spatial Navigation*

Associated data

  • Dryad/10.5061/dryad.2280gb5tx