Lack of Association of rs12702634 in RPA3-UMAD1 With Interstitial Lung Diseases in Japanese Rheumatoid Arthritis Patients

Takashi Higuchi; Shomi Oka; Hiroshi Furukawa; Kota Shimada; Shigeto Tohma

doi:10.1177/11772719221091758

Lack of Association of rs12702634 in RPA3-UMAD1 With Interstitial Lung Diseases in Japanese Rheumatoid Arthritis Patients

Biomark Insights. 2022 Apr 15:17:11772719221091758. doi: 10.1177/11772719221091758. eCollection 2022.

Authors

Takashi Higuchi^{1

2}, Shomi Oka^{1

3}, Hiroshi Furukawa^{1

3}, Kota Shimada^{3

4}, Shigeto Tohma^{1

3}

Affiliations

¹ Department of Clinical Research, National Hospital Organization Tokyo National Hospital, Kiyose, Japan.
² Department of Nephrology, Ushiku Aiwa General Hospital, Ushiku, Japan.
³ Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Minami-ku, Sagamihara, Japan.
⁴ Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchu, Japan.

Abstract

Background: Rheumatoid arthritis (RA) is occasionally complicated with interstitial lung disease (ILD). A recent genome-wide association study of ILD in RA reported an association with the polymorphism rs12702634 in RPA3-UMAD1. We conducted an association study of this variant with ILD in Japanese RA patients to replicate this association.

Methods: Genotyping of rs12702634 was performed in 175 RA with ILD and 411 RA without chronic lung disease.

Results: No association was detected for rs12702634 with ILD in RA (P = .6369, odds ratio [OR] 1.13, 95% confidence interval [CI] 0.72-1.78). Meta-analysis of these data combined with the data from the recent report showed no significant association (P = .0996, OR 1.52, 95% CI 0.92-2.49).

Conclusions: The present study demonstrated no association of RPA3-UMAD1 rs12702634 with ILD in RA, suggesting the heterogeneity of the disease.

Keywords: Rheumatoid arthritis; extraarticular manifestation; genetic association; interstitial lung diseases; polymorphism.