Pathogenesis and prevention of intraventricular hemorrhage

Aisling A Garvey; Brian H Walsh; Terrie E Inder

doi:10.1016/j.semperi.2022.151592

Pathogenesis and prevention of intraventricular hemorrhage

Semin Perinatol. 2022 Aug;46(5):151592. doi: 10.1016/j.semperi.2022.151592. Epub 2022 Mar 12.

Authors

Aisling A Garvey¹, Brian H Walsh², Terrie E Inder³

Affiliations

¹ Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.
² Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Neonatology, Cork University Maternity Hospital, Cork, Ireland.
³ Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: tinder@bwh.harvard.edu.

PMID: 35450738
DOI: 10.1016/j.semperi.2022.151592

Abstract

Despite improvements in the mortality rates of preterm infants, rates of germinal matrix intraventricular hemorrhage (IVH) have remained static with an overall incidence of 25% in infants less than 32 weeks. The importance of the lesion relates primarily to the underlying injury to the developing brain and the associated long-term neurodevelopmental consequences. This clinical-orientated review focuses on the pathogenesis of IVH and discusses the evidence behind proposed prevention strategies.

MeSH terms

Brain
Cerebral Hemorrhage / complications
Cerebral Hemorrhage / epidemiology
Cerebral Hemorrhage / prevention & control
Cerebral Ventricles / pathology
Head
Humans
Infant
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases* / etiology
Infant, Premature, Diseases* / prevention & control