Obsessive-Compulsive Disorder (OCD) is one disabling psychiatric condition. Investigations reported the effectiveness of trans-cranial direct current stimulation (tDCS) in regulating orbito-fronto-striato-pallido-thalamic network activity in OCD patients. In these patients, hypo- or hyper-activity of different brain areas including orbitofrontal cortex (OFC), pre-supplementary motor area (pre-SMA), cingulate gyrus, putamen, thalamus, parietal cortex and cerebellum have been reported.The purpose of this study is determination the efficacy of three different tDCS protocols and finding the best one to mitigate OCD symptoms.This study was a quasi-experimental research with pre-test-post-test and a one-month follow-up. Of the patients that referred to Brain and Cognitive Clinic in Tehran, 40 OCD subjects were randomly selected and assigned into four groups (three experimental groups and one control group). Of the mentioned patients, those who scored 16 or above on the Yale-Brown obsessive-compulsive scale were chosen. tDCS was delivered over a period of 5 days at an intensity of 2 mA for 15 minutes twice a day. In the three intervention groups, tDCS was delivered in one of the following electrode montages: (i) anode over the right cerebellum (O2) and cathode over the supplementary motor area (pre-SMA; c3/c4); (ii) anode over O2 and cathode over the left OFC (FP1); or (iii) anode over O2 and cathode over the left cerebellum (O1). The control group received sham stimulation (anode over O2 and cathode over the left FP1). Analysis of covariance (ANCOVA) was used to evaluate the results.The results showed that two of the tDCS protocols reduced OCD symptoms (P < 0.001). Data also revealed that the effect of the anodal stimulation of the O2 led to better outputs as compared to O1..
Keywords: Transcranial direct current stimulation (tDCS); brain stimulation; cerebellum; obsessive compulsive disorder (OCD); orbitofrontal cortex (OFC).