Disorders of neuronal migration

Can J Neurol Sci. 1987 Feb;14(1):1-16. doi: 10.1017/s031716710002610x.


Neuronal migration constitutes one of the major processes by which the central nervous system takes shape. Detailed knowledge about this important process now exists for different brain regions in rodent and monkey models as well as in the human. In the human, distinct genetic, chromosomal and environmental causes are known that affect neuronal migration, often in a morphologically distinct pattern, but the underlying pathological mechanisms are largely unknown. This review is intended to integrate our basic knowledge of the field with the accumulated intelligence on a large number of disorders and syndromes that represent the human part of the story.

Publication types

  • Review

MeSH terms

  • Abnormalities, Multiple / embryology
  • Abnormalities, Multiple / etiology
  • Brain / abnormalities*
  • Brain / embryology
  • Cell Movement / drug effects
  • Cell Movement / radiation effects
  • Female
  • Humans
  • Male
  • Nervous System Diseases / embryology*
  • Nervous System Diseases / etiology
  • Neurons / drug effects
  • Neurons / pathology
  • Neurons / physiology*
  • Neurons / radiation effects
  • Pregnancy