Effect of heparin concentration and infusion rate on the patency of arterial catheters

Crit Care Med. 1987 Mar;15(3):230-2. doi: 10.1097/00003246-198703000-00010.


In a prospective randomized controlled trial involving 470 arterial catheters in 470 children, we studied the effect of changing either the concentration or the flow rate of a heparin infusion. Although catheters tended to remain patent longer with a flow rate of 2 ml/h rather than 1 ml/h, the difference was not statistically significant. Increasing the heparin concentration from 1 to 5 U/ml significantly prolonged catheter patency.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Arteries
  • Catheters, Indwelling*
  • Child
  • Clinical Trials as Topic
  • Heparin / administration & dosage*
  • Humans
  • Infusions, Intra-Arterial
  • Prospective Studies
  • Random Allocation
  • Regression Analysis
  • Time Factors


  • Heparin