Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation

Int J Clin Pharmacol Ther Toxicol. 1986 Dec;24(12):651-4.


A new model for evaluating nonsteroidal anti-inflammatory drugs (NSAIDs) is described. In this model of postoperative inflammation, the anti-inflammatory activity of curcumin (diferuloyl methane) was investigated in comparison with phenylbutazone and placebo. Phenylbutazone and curcumin produced a better anti-inflammatory response than placebo.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Catechols / therapeutic use*
  • Clinical Trials as Topic
  • Curcumin / therapeutic use*
  • Double-Blind Method
  • Humans
  • Inflammation / drug therapy*
  • Male
  • Middle Aged
  • Phenylbutazone / therapeutic use
  • Postoperative Complications / drug therapy*
  • Random Allocation


  • Anti-Inflammatory Agents, Non-Steroidal
  • Catechols
  • Phenylbutazone
  • Curcumin