Hypertension and Heart Failure: Prevention, Targets, and Treatment

Cardiol Clin. 2022 May;40(2):237-244. doi: 10.1016/j.ccl.2021.12.011.


Hypertension is possibly the most powerful, modifiable risk factor for the development of heart failure. Chronic hypertension drives cardiac remodeling within the left ventricle resulting in hypertensive heart disease, which ultimately manifests as heart failure. Early detection and appropriate management are necessary to prevent heart failure as well as other cardiovascular diseases. Achieving blood pressure goals in conjunction with using evidence-based treatments can improve clinical outcomes for patients with comorbid hypertension and heart failure.

Keywords: Heart failure; Hypertension; Pharmacotherapy; Risk reduction.

Publication types

  • Review

MeSH terms

  • Antihypertensive Agents / pharmacology
  • Antihypertensive Agents / therapeutic use
  • Blood Pressure
  • Cardiovascular Diseases* / drug therapy
  • Heart Failure* / etiology
  • Heart Failure* / prevention & control
  • Humans
  • Hypertension* / complications
  • Hypertension* / diagnosis
  • Hypertension* / therapy


  • Antihypertensive Agents