A review on characterization, applications and structure-activity relationships of Bacillus species-produced bacteriocins

Drug Discov Ther. 2022 May 17;16(2):55-62. doi: 10.5582/ddt.2021.01087. Epub 2022 Apr 23.


Antimicrobial peptides (AMPs) are inherently occurring proteins that are produced by microorganisms as secondary metabolites. Members of genus Bacillus produce many types of AMPs by ribosomal (bacteriocins) and non-ribosomal (polymyxins and iturins) mechanisms. Bacteriocins are ribosomally synthesized peptides that inhibit the growth of closely related bacterial strains. Moreover, bacteriocins produced by Bacillus species have been widely used in pharmaceutical, food industry, fishery, livestock as well as in agriculture sector. The objective of this review is to assess the characterization of the Bacillus-derived bacteriocins, their potential use in different sectors and structure-activity relationships.

Keywords: Antimicrobial agents; bacteriocin-like inhibitory substance (BLIS); lantibiotics; probiotics.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Bacillus* / metabolism
  • Bacteria / metabolism
  • Bacteriocins* / chemistry
  • Bacteriocins* / metabolism
  • Bacteriocins* / pharmacology
  • Structure-Activity Relationship


  • Anti-Bacterial Agents
  • Bacteriocins