Measurement of glomerular filtration rate with technetium-99m DTPA: comparison of plasma clearance techniques

J Nucl Med. 1987 Mar;28(3):372-7.


We have compared several techniques for measuring [99mTc]DTPA plasma clearance following single injection to estimate glomerular filtration rate (GFR). Half hourly measurements of disappearance of plasma activity were used to calculate a reference GFR corrected for one-pool assumption and body surface area. Alternative methods involving (i) single blood sample, (ii) two blood samples, (iii) external detector clearance rate, and (iv) a combination of (i) and (iii) were then compared. Closest correlations were obtained with (i) two blood samples at 2 hr and 4 hr (s.e.e. 2.8 ml/min) and (i.v.) external rate constant from 2-5 hr with a blood sample at 3 hr (s.e.e. 3.0 ml/min). Correlations with single blood sample were closest at 3 hr and 4 hr postinjection (s.e.e. 5.4 and 4.5 ml/min, respectively). External detector disappearance rate constant alone was least accurate (s.e.e. greater than 10 ml. min).

Publication types

  • Comparative Study

MeSH terms

  • Glomerular Filtration Rate*
  • Humans
  • Kinetics
  • Mathematics
  • Metabolic Clearance Rate
  • Pentetic Acid* / blood
  • Radioisotope Renography / methods*
  • Technetium Tc 99m Pentetate
  • Technetium* / blood
  • Time Factors


  • Technetium
  • Pentetic Acid
  • Technetium Tc 99m Pentetate