Symptom Association for Gastroesophageal Reflux Disease by pH Monitoring After Peroral Endoscopic Myotomy

Am J Gastroenterol. 2022 Aug 1;117(8):1316-1319. doi: 10.14309/ajg.0000000000001801. Epub 2022 Apr 25.


Introduction: There are limited data correlating symptoms with reflux episodes during pH studies after peroral endoscopic myotomy.

Methods: Consecutive patients who underwent POEM followed up ≥6 months later by 48-hour ambulatory wireless pH testing off antisecretory therapy were identified. Reflux symptom association was defined as symptom association probability >95%.

Results: The most frequent symptoms of heartburn (47.2%), cough (45.1%), and chest pain (39.6%) were associated with a positive reflux symptom association (symptom association probability >95%) in 20.9%, 17.1%, and 19.4%, respectively.

Discussion: There is poor correlation between reported symptoms and esophageal acid exposure during pH testing after POEM.

Trial registration: NCT02770859.

MeSH terms

  • Esophageal Achalasia* / complications
  • Esophageal Achalasia* / surgery
  • Esophagitis, Peptic*
  • Esophagoscopy
  • Gastroesophageal Reflux* / complications
  • Gastroesophageal Reflux* / etiology
  • Heartburn / etiology
  • Humans
  • Hydrogen-Ion Concentration
  • Myotomy*
  • Natural Orifice Endoscopic Surgery*
  • Treatment Outcome

Associated data