Risk of Appendicitis After mRNA COVID-19 Vaccination in a Danish Population

doi:10.1001/jamainternmed.2022.1222

. 2022 Jun 1;182(6):684-686.

doi: 10.1001/jamainternmed.2022.1222.

Risk of Appendicitis After mRNA COVID-19 Vaccination in a Danish Population

Helene Kildegaard¹, Louise Ladebo¹, Jacob Harbo Andersen¹, Peter Bjødstrup Jensen¹, Lotte Rasmussen¹, Per Damkier^{1

2

3}, Anton Pottegård^{1

4}

Affiliations

¹ Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense.
² Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark.
³ Department of Clinical Research, University of Southern Denmark, Odense.
⁴ Hospital Pharmacy Funen, Odense University Hospital, Odense, Denmark.

PMID: 35467699
PMCID: PMC9039823
DOI: 10.1001/jamainternmed.2022.1222

Risk of Appendicitis After mRNA COVID-19 Vaccination in a Danish Population

Helene Kildegaard et al. JAMA Intern Med. 2022.

. 2022 Jun 1;182(6):684-686.

doi: 10.1001/jamainternmed.2022.1222.

Authors

Helene Kildegaard¹, Louise Ladebo¹, Jacob Harbo Andersen¹, Peter Bjødstrup Jensen¹, Lotte Rasmussen¹, Per Damkier^{1

2

3}, Anton Pottegård^{1

4}

Affiliations

¹ Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense.
² Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark.
³ Department of Clinical Research, University of Southern Denmark, Odense.
⁴ Hospital Pharmacy Funen, Odense University Hospital, Odense, Denmark.

PMID: 35467699
PMCID: PMC9039823
DOI: 10.1001/jamainternmed.2022.1222

Abstract

This cohort study used data from Danish registers to assess whether recipients of mRNA COVID-19 vaccines had a higher risk of appendicitis after receiving the shot compared with individuals who did not receive the vaccine.

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Conflict of interest statement

Conflict of Interest Disclosures: Ms Rasmussen reported receiving support through the University of Southern Denmark from Novo Nordisk outside the submitted work. Mr Pottegård reported receiving grants from Alcon, Almirall, Astellas Pharma, AstraZeneca, Boehringer Ingelheim, Novo Nordisk, Servier, and LEO Pharma outside the submitted work. No other disclosures were reported.

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References

1. US Food and Drug Administration . Vaccines and related biological products advisory committee December 10, 2020. meeting announcement. December 10, 2020. Accessed December 14, 2021. https://www.fda.gov/advisory-committees/advisory-committee-calendar/vacc...
1. Mitchell J, Yue QY. Appendicitis as a possible safety signal for the COVID-19 vaccines. Vaccine X. 2021;9:100122. doi:10.1016/j.jvacx.2021.100122 - DOI - PMC - PubMed
1. Barda N, Dagan N, Ben-Shlomo Y, et al. . Safety of the BNT162b2 mRNA Covid-19 vaccine in a nationwide setting. N Engl J Med. 2021;385(12):1078-1090. doi:10.1056/NEJMoa2110475 - DOI - PMC - PubMed
1. US Food and Drug Administration . COVID-19 vaccine safety surveillance. December 7, 2021, Accessed March 2, 2022. https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologi...
1. Klein NP, Lewis N, Goddard K, et al. . Surveillance for adverse events after COVID-19 mRNA vaccination. JAMA. 2021;326(14):1390-1399. doi:10.1001/jama.2021.15072 - DOI - PMC - PubMed

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[1] US Food and Drug Administration . Vaccines and related biological products advisory committee December 10, 2020. meeting announcement. December 10, 2020. Accessed December 14, 2021. https://www.fda.gov/advisory-committees/advisory-committee-calendar/vacc...

[2] US Food and Drug Administration . Vaccines and related biological products advisory committee December 10, 2020. meeting announcement. December 10, 2020. Accessed December 14, 2021. https://www.fda.gov/advisory-committees/advisory-committee-calendar/vacc...

[3] Mitchell J, Yue QY. Appendicitis as a possible safety signal for the COVID-19 vaccines. Vaccine X. 2021;9:100122. doi:10.1016/j.jvacx.2021.100122 - DOI - PMC - PubMed

[4] Mitchell J, Yue QY. Appendicitis as a possible safety signal for the COVID-19 vaccines. Vaccine X. 2021;9:100122. doi:10.1016/j.jvacx.2021.100122 - DOI - PMC - PubMed

[5] Barda N, Dagan N, Ben-Shlomo Y, et al. . Safety of the BNT162b2 mRNA Covid-19 vaccine in a nationwide setting. N Engl J Med. 2021;385(12):1078-1090. doi:10.1056/NEJMoa2110475 - DOI - PMC - PubMed

[6] Barda N, Dagan N, Ben-Shlomo Y, et al. . Safety of the BNT162b2 mRNA Covid-19 vaccine in a nationwide setting. N Engl J Med. 2021;385(12):1078-1090. doi:10.1056/NEJMoa2110475 - DOI - PMC - PubMed

[7] US Food and Drug Administration . COVID-19 vaccine safety surveillance. December 7, 2021, Accessed March 2, 2022. https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologi...

[8] US Food and Drug Administration . COVID-19 vaccine safety surveillance. December 7, 2021, Accessed March 2, 2022. https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologi...

[9] Klein NP, Lewis N, Goddard K, et al. . Surveillance for adverse events after COVID-19 mRNA vaccination. JAMA. 2021;326(14):1390-1399. doi:10.1001/jama.2021.15072 - DOI - PMC - PubMed

[10] Klein NP, Lewis N, Goddard K, et al. . Surveillance for adverse events after COVID-19 mRNA vaccination. JAMA. 2021;326(14):1390-1399. doi:10.1001/jama.2021.15072 - DOI - PMC - PubMed

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Risk of Appendicitis After mRNA COVID-19 Vaccination in a Danish Population

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Risk of Appendicitis After mRNA COVID-19 Vaccination in a Danish Population

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