Current Update of Phytotherapeutic Agents in the Treatment of COVID-19: In-Silico Based Virtual Screening Approach for the Development of Antiviral Drug

Front Biosci (Landmark Ed). 2022 Apr 2;27(4):123. doi: 10.31083/j.fbl2704123.


COVID-19, caused by the severe acquired respiratory syndrome coronavirus-2 (SARS-CoV-2), is a highly contagious disease that has emerged as a pandemic. Researchers and the medical fraternity are working towards the identification of anti-viral drug candidates. Meanwhile, several alternative treatment approaches are being explored to manage the disease effectively. Various phyto-drugs and essential oils have been reported to have antiviral activity, but this has not been well studied in the context of SARS-CoV-2. The main focus of this review is on the biology of infection and the different therapeutic strategies involved, including drug repurposing and phytopharmaceuticals. The role of phytochemicals in treating COVID-19 and various other diseases has also been emphasized.

Keywords: ACE II receptors; COVID-19; SARS-CoV-2; essential oils; ethnomedicine; phyto-drugs.

Publication types

  • Review

MeSH terms

  • Antiviral Agents* / therapeutic use
  • COVID-19* / drug therapy
  • Humans
  • SARS-CoV-2


  • Antiviral Agents