Rapid eye movement sleep behaviour disorder: Past, present, and future

J Sleep Res. 2022 Aug;31(4):e13612. doi: 10.1111/jsr.13612. Epub 2022 Apr 25.


This manuscript presents an overview of REM sleep behaviour disorder (RBD) with a special focus on European contributions. After an introduction examining the history of the disorder, we address the pathophysiological and clinical aspects, as well as the diagnostic issues. Further, implications of RBD diagnosis and biomarkers are discussed. Contributions of European researchers to this field are highlighted.

Keywords: RBD; REM sleep without atonia; REM-parasomnia; RWA; alpha-synuclein; dream enactment.

Publication types

  • Review

MeSH terms

  • Humans
  • Polysomnography
  • REM Sleep Behavior Disorder* / diagnosis
  • Sleep, REM / physiology