An effective rhodium(III) catalysis for the construction of valuable tetracyclic compounds is described herein. This domino process involving the C-H activation/[3 + 2] annulation/intramolecular Friedel-Crafts reaction sequences of simple and readily available N-Boc hydrazones and propargylic monofluoroalkynes afforded fused tetracyclic spiro[cyclobutane-1,9'-indeno[1,2-a]indenes] in moderate to good yields, featuring three C-C bond formation. Moreover, control experiments indicated that the C-H activation might be involved in the rate-determining step.