Streptozyme test for antibodies to group A streptococcal antigens

Pediatr Infect Dis J. 1987 Jan;6(1):36-40. doi: 10.1097/00006454-198701000-00010.


The ability of the Streptozyme test to identify significant antibody rises in 46 patients with streptococcal pharyngitis was comparable to, but no greater than, that of the antistreptolysin O or antideoxyribonuclease B test and inferior to that of the combined use of both the antistreptolysin O and antideoxyribonuclease B tests. Serum specimens were also simultaneously analyzed with three different lots of Streptozyme reagent. Lot-to-lot variation in the reagent resulted in a significant difference in antibody titer for 18 (19%) of the 92 sera tested. Differences among the three lots also produced variation in determining whether a significant rise in titer had occurred from the acute phase to the convalescent phase serum for a given patient. These observations raise concerns about the standardization of the Streptozyme reagent and document the need for precise identification and quantitation of the streptococcal antigens used in this product.

Publication types

  • Comparative Study

MeSH terms

  • Antibodies, Bacterial / analysis*
  • Antigens, Bacterial / immunology
  • Bacterial Proteins
  • Deoxyribonucleases
  • Hemagglutination Tests
  • Humans
  • Hydrolases* / immunology
  • Pharyngitis / diagnosis*
  • Pharyngitis / immunology
  • Serologic Tests
  • Streptococcal Infections / diagnosis*
  • Streptococcal Infections / immunology
  • Streptococcus pyogenes / immunology*
  • Streptokinase / immunology
  • Streptolysins / immunology


  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Proteins
  • Streptolysins
  • streptolysin O
  • streptozyme test
  • Hydrolases
  • Deoxyribonucleases
  • deoxyribonuclease B
  • Streptokinase