Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Sep;47(9):1673-1678.
doi: 10.1111/ced.15239. Epub 2022 Jun 22.

The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis

Ceren Gül  1 , Sevilay Kilic  1 , Müşerref Hilal Şehitoğlu  2
Affiliations

The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis

Ceren Gül et al. Clin Exp Dermatol. 2022 Sep.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Clin Exp Dermatol. 2022 Dec;47(12):2349. doi: 10.1111/ced.15390. Clin Exp Dermatol. 2022. PMID: 36440613 No abstract available.

Abstract

Background: Psoriasis is a chronic inflammatory skin disorder characterized by inflammation, hyperproliferation and neoangiogenesis. The disease pathogenesis has not been fully elucidated. The proteins, a disintegrin and metalloproteinase (ADAM)10 and ADAM17, are important proteases serving as regulators of inflammation.

Aim: To determine the role of ADAM10 and ADAM17 in the pathogenesis of psoriasis through the comparison of their serum levels in patients with psoriasis and healthy controls (HCs).

Methods: In total, 179 participants (90 patients with psoriasis and 89 HCs) were enrolled in the study. Levels of ADAM10 and ADAM17 in serum were measured by ELISA for each participant from the patient and HC groups. The statistical data analysis was performed using SPSS (V19.0) and P < 0.05 was considered statistically significant.

Results: The mean values for serum ADAM10 and ADAM17 were, respectively, 3.1 ± 2.2 and 76.5 ± 31.1 in the psoriasis group and 8.6 ± 3.7 and 29.5 ± 22.4 in the HC group. A statistically significant difference between the patient and HC groups was detected for both ADAM10 and ADAM17 levels (P = 0.001).

Conclusion: Considering the high levels of ADAM17 in the psoriasis group, ADAM17 protease might have a crucial role in the pathogenesis of psoriasis, while the low levels of ADAM10 might be attributable to its regulatory effect on keratinocyte differentiation and proliferation.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Hugh JM, Weinberg JM. Update on the pathophysiology of psoriasis. Cutis 2018; 102: 6-12.
    1. Moss ML, Jin S-LC, Milla ME et al. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α. Nature 1997; 385: 733-6.
    1. Black RA, Rauch CT, Kozlosky CJ et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells. Nature 1997; 385: 729-33.
    1. Scheller J, Chalaris A, Garbers C et al. ADAM17: a molecular switch to control inflammation and tissue regeneration. Trends Immunol 2011; 32: 380-7.
    1. Yong Bae W, Kook Park S, Hun Kim D et al. Expression of ADAM17 and ADAM10 in nasal polyps. Int Forum Allergy Rhinol 2016; 6: 731-6.