A walk through the SMC cycle: From catching DNAs to shaping the genome

Roel Oldenkamp; Benjamin D Rowland

doi:10.1016/j.molcel.2022.04.006

A walk through the SMC cycle: From catching DNAs to shaping the genome

Mol Cell. 2022 May 5;82(9):1616-1630. doi: 10.1016/j.molcel.2022.04.006. Epub 2022 Apr 26.

Authors

Roel Oldenkamp¹, Benjamin D Rowland²

Affiliations

¹ Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
² Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address: b.rowland@nki.nl.

PMID: 35477004
DOI: 10.1016/j.molcel.2022.04.006

Abstract

SMC protein complexes are molecular machines that provide structure to chromosomes. These complexes bridge DNA elements and by doing so build DNA loops in cis and hold together the sister chromatids in trans. We discuss how drastic conformational changes allow SMC complexes to build such intricate DNA structures. The tight regulation of these complexes controls fundamental chromosomal processes such as transcription, recombination, repair, and mitosis.

Keywords: 3D genome; CTCF; SMC complexes; chromosome condensation; cohesin; condensin; loop extrusion; sister chromatid cohesion.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Cycle Proteins* / metabolism
Chromatids / metabolism
Chromosomal Proteins, Non-Histone* / genetics
Chromosomal Proteins, Non-Histone* / metabolism
DNA / genetics
Mitosis / genetics

Substances

Cell Cycle Proteins
Chromosomal Proteins, Non-Histone
DNA