Two-photon excitable boron complex based on tridentate imidazo[1,5- a]pyridine ligand for heavy-atom-free mitochondria-targeted photodynamic therapy

Keita Hoshi; Masami Itaya; Koki Tahara; Airi Matsumoto; Atsuhi Tabata; Hideaki Nagamune; Yasushi Yoshida; Eiji Hase; Takeo Minamikawa; Takeshi Yasui; Tetsuro Katayama; Akihiro Furube; Keiji Minagawa; Yasushi Imada; Fumitoshi Yagishita

doi:10.1039/d1ra05059a

Two-photon excitable boron complex based on tridentate imidazo[1,5- a]pyridine ligand for heavy-atom-free mitochondria-targeted photodynamic therapy

RSC Adv. 2021 Aug 2;11(42):26403-26407. doi: 10.1039/d1ra05059a. eCollection 2021 Jul 27.

Authors

Affiliations

¹ Department of Applied Chemistry, Tokushima University 2-1 Minamijosanjima Tokushima 770-8506 Japan yagishitaf@tokushima-u.ac.jp.
² Department of Bioscience and Bioindustry, Tokushima University 2-1 Minamijosanjima Tokushima 770-8513 Japan.
³ Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University 1-33 Yayoi-cho, Inage-ku Chiba 263-8522 Japan.
⁴ Department of Post-LED Photonics Research, Institute of Post-LED Photonics, Tokushima University 2-1 Minamijosanjima Tokushima 770-8506 Japan.

Abstract

We have synthesized a cyan fluorescent boron complex based on a tridentate imidazo[1,5-a]pyridine ligand. The boron complex was found to have potential applications as not only a chiroptical material but also a heavy-atom-free mitochondria-targeted photosensitizer for cancer treatment.