Blue nevi of the palpebral conjunctiva: report of 2 cases and review of literature

Orbit. 2022 Oct;41(5):527-534. doi: 10.1080/01676830.2022.2065315. Epub 2022 Apr 28.


Purpose: To describe two patients with blue nevi of the palpebral conjunctiva and to review the existing literature on common and cellular blue nevi of the conjunctiva.

Methods: Report of two cases and literature review.

Results: We present two cases of blue nevi in the palpebral conjunctiva: an atypical cellular blue nevus of the left upper eyelid and a common blue nevus around the lacrimal punctum of the left lower eyelid. Both patients underwent full thickness eyelid excision with wide margins. There was no tumor recurrence at 11 and 4 months postoperatively.

Conclusions: Blue nevi are a group of melanocytic tumors that rarely involve the ocular adnexa. They may arise in the palpebral conjunctiva and should be considered in the differential diagnosis of pigmented lesions in this location as they can mimic melanoma.

Keywords: Atypical cellular blue nevus; blue nevus of the conjunctiva; blue nevus of the palpebral conjunctiva; cellular blue nevus; common blue nevus.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Conjunctiva / pathology
  • Conjunctival Neoplasms* / diagnosis
  • Diagnosis, Differential
  • Humans
  • Neoplasm Recurrence, Local / pathology
  • Nevus, Blue* / diagnosis
  • Nevus, Blue* / pathology
  • Nevus, Blue* / surgery
  • Skin Neoplasms* / pathology
  • Syndrome