Movement disorders associated with antiseizure medications: A systematic review

Epilepsy Behav. 2022 Jun;131(Pt A):108693. doi: 10.1016/j.yebeh.2022.108693. Epub 2022 Apr 25.


New-onset movement disorders have been frequently reported in association with the use of antiseizure medications (ASMs). The frequency of specific motor manifestations and the spectrum of their semiology for various ASMs have not been well characterized. We carried out a systematic review of literature and conducted a search on CINAHL, Cochrane Library, EMBASE, MEDLINE, PsycINFO, and Scopus from inception to April 2021. We compiled the data for all currently available ASMs using the conventional terminology of movement disorders. Among 5123 manuscripts identified by the search, 437 met the inclusion criteria. The largest number of reports of abnormal movements were in association with phenobarbital, valproic acid, lacosamide, and perampanel, and predominantly included tremor and ataxia. The majority of attempted interventions for all agents were discontinuation of the offending drug or dose reduction which led to the resolution of symptoms in most patients. Familiarity with the movement disorder phenomenology previously encountered in relation with specific ASMs facilitates early recognition of adverse effects and timely institution of targeted interventions.

Keywords: Adverse effects; Antiseizure medications; Drug-induced; Movement disorder.

Publication types

  • Review
  • Systematic Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Anticonvulsants* / adverse effects
  • Humans
  • Lacosamide
  • Movement Disorders* / drug therapy
  • Movement Disorders* / etiology
  • Phenobarbital
  • Valproic Acid


  • Anticonvulsants
  • Lacosamide
  • Valproic Acid
  • Phenobarbital