Since January 2022, acute severe hepatitis cases with unknown etiology in children have occurred in many countries in Europe and the United States, and 43.8% of the cases were positive for human adenovirus (HAdV), and some cases were identified as HAdV-41. However, more evidences including etiology, genomics, liver pathology, and immunohistochemistry are needed to determine the main cause of this outbreak. At present, due to the lack of systematic surveillance and research on hepatitis caused by HAdV infection, it is impossible to determine whether there are similar hepatitis cases occurred in China. It is urgent to carry out HAdV virolgocial surveillance based on clinical symptom, and potential risk of acute severe hepatitis should be studied as soon as possible according to the available relevant clinical, epidemiological and virological data, as well as risk factor information, which will provide scientific and technical support for the prevention and control of HAdV-related diseases.
自2022年1月以来，欧美多个国家出现了不明原因儿童急性严重肝炎病例，实验室检测发现43.8%的病例为人腺病毒（HAdV）阳性，且部分病例鉴定为HAdV-41。然而，引发此次儿童严重肝炎疫情的病因还需要更多的病原学、基因组学、肝脏病理、免疫组化和电镜等证据来确定。目前，HAdV导致的肝炎尚无系统的监测研究，因而无法判断我国目前是否存在类似肝炎病例，因此急需开展以临床症状监测为基础的HAdV病原学监测，尽快收集相关临床、流行病学和病毒学监测数据以及风险因素信息，研判不明原因儿童急性严重肝炎在我国发生的潜在风险，同时也为我国HAdV相关疾病的防控、预测预警以及疫苗和药物的研发提供科学技术支撑。.