Evaluation of the predictive role of anterior uterocervical angle in preterm labor in twin gestation through meta-analysis: anterior uterocervical angle and preterm labor in twin gestation

J Gynecol Obstet Hum Reprod. 2022 Jun;51(6):102397. doi: 10.1016/j.jogoh.2022.102397. Epub 2022 Apr 27.


Multiple gestations are high-risk pregnancies with increased obstetric and perinatal risks. Preterm labor occurs in about half of twin pregnancies. Thus, prediction of the time of delivery and prevention of premature birth are very important in multiple gestations. Anterior uterocervical angle is a successful tool that has been used in the prediction of preterm labor in recent years. However there is only limited data about this issue for twin pregnancies in the literature. Here, we aimed to demonstrate the relationship between uterocervical angle and preterm labor in twin pregnancies more clearly and reliably with this meta-analysis. In this context, "twin gestation, uterocervical angle, cervical angle, angle, cervix, cervical, preterm and preterm labor" keywords were used and PubMed, Medline, ClinicalKey, Scopus, Science Direct, Web of Science, and Google Scholar database were searched between 1 January 2010 and 27 December 2020. Finally, a total of three studies were included in the analysis. Here, we found that uterocervical angle was associated with a higher risk of preterm delivery in the overall effect.

Keywords: meta-analysis; multiple gestation; preterm labor; uterocervical angle.

Publication types

  • Meta-Analysis

MeSH terms

  • Cervical Length Measurement
  • Cervix Uteri / diagnostic imaging
  • Female
  • Humans
  • Infant, Newborn
  • Obstetric Labor, Premature*
  • Pregnancy
  • Premature Birth* / prevention & control
  • Uterus / diagnostic imaging