Simultaneous Liver-Kidney Transplantation

Clin Liver Dis. 2022 May;26(2):313-322. doi: 10.1016/j.cld.2022.01.011. Epub 2022 Apr 1.

Abstract

End-stage kidney disease (ESKD) after liver transplantation is associated with high morbidity and mortality. This increase in mortality can be offset by performing a kidney transplant at the time of the liver transplant in select cases. Accordingly, Margreiter and colleague; s performed the first simultaneous liver-kidney (SLK) transplant in 1983. The number of SLK transplants has increased by more than 300% since then. In 1990%, 1.7% of all liver transplants in the United States were SLK transplants which increased to 9.9% by 2016. This steep increase was likely due to the implementation of the model of end-stage liver disease (MELD) scoring system in 2002, which is heavily weighted by serum creatinine.

Keywords: End-stage kidney disease; Liver transplantation; Liver–kidney transplantation; end-stage liver disease.

Publication types

  • Review

MeSH terms

  • Humans
  • Kidney
  • Kidney Transplantation*
  • Liver
  • Liver Transplantation*
  • Treatment Outcome
  • United States