Monash DaCRA fPET-fMRI: A dataset for comparison of radiotracer administration for high temporal resolution functional FDG-PET

Sharna D Jamadar; Emma X Liang; Shenjun Zhong; Phillip G D Ward; Alexandra Carey; Richard McIntyre; Zhaolin Chen; Gary F Egan

doi:10.1093/gigascience/giac031

Monash DaCRA fPET-fMRI: A dataset for comparison of radiotracer administration for high temporal resolution functional FDG-PET

Gigascience. 2022 Apr 30:11:giac031. doi: 10.1093/gigascience/giac031.

Authors

Sharna D Jamadar^{1

2

3}, Emma X Liang¹, Shenjun Zhong^{1

4}, Phillip G D Ward^{1

3}, Alexandra Carey^{1

5}, Richard McIntyre^{1

5}, Zhaolin Chen^{1

6}, Gary F Egan^{1

2

3}

Affiliations

¹ Monash Biomedical Imaging, Monash University, Melbourne, VIC 3800, Australia.
² Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC 3800, Australia.
³ Australian Research Council Centre of Excellence for Integrative Brain Function, 3800 Australia.
⁴ National Imaging Facility, 4072, Australia.
⁵ Department of Medical Imaging, Monash Health, VIC 3800, Australia.
⁶ Monash Data Futures Institute, Monash University , Melbourne, VIC 3800, Australia.

Abstract

Background: "Functional" [18F]-fluorodeoxyglucose positron emission tomography (FDG-fPET) is a new approach for measuring glucose uptake in the human brain. The goal of FDG-fPET is to maintain a constant plasma supply of radioactive FDG in order to track, with high temporal resolution, the dynamic uptake of glucose during neuronal activity that occurs in response to a task or at rest. FDG-fPET has most often been applied in simultaneous BOLD-fMRI/FDG-fPET (blood oxygenation level-dependent functional MRI fluorodeoxyglucose functional positron emission tomography) imaging. BOLD-fMRI/FDG-fPET provides the capability to image the 2 primary sources of energetic dynamics in the brain, the cerebrovascular haemodynamic response and cerebral glucose uptake.

Findings: In this Data Note, we describe an open access dataset, Monash DaCRA fPET-fMRI, which contrasts 3 radiotracer administration protocols for FDG-fPET: bolus, constant infusion, and hybrid bolus/infusion. Participants (n = 5 in each group) were randomly assigned to each radiotracer administration protocol and underwent simultaneous BOLD-fMRI/FDG-fPET scanning while viewing a flickering checkerboard. The bolus group received the full FDG dose in a standard bolus administration, the infusion group received the full FDG dose as a slow infusion over the duration of the scan, and the bolus-infusion group received 50% of the FDG dose as bolus and 50% as constant infusion. We validate the dataset by contrasting plasma radioactivity, grey matter mean uptake, and task-related activity in the visual cortex.

Conclusions: The Monash DaCRA fPET-fMRI dataset provides significant reuse value for researchers interested in the comparison of signal dynamics in fPET, and its relationship with fMRI task-evoked activity.

Keywords: blood oxygenation level–dependent functional magnetic resonance imaging; fluorodeoxyglucose positron emission tomography; functional MRI; functional PET; human neuroimaging; human neuroscience; radiotracer administration; simultaneous PET/MR.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Brain / diagnostic imaging
Fluorodeoxyglucose F18*
Glucose
Humans
Magnetic Resonance Imaging* / methods
Positron-Emission Tomography / methods

Substances

Fluorodeoxyglucose F18
Glucose